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Are We All Toxic?
Submitted by Thorne Research, Inc.

In the last 50 years, our environment has become increasingly more polluted. This has resulted in a greater human toxic burden than ever before. Unfortunately, tens of thousands of toxic chemicals have been introduced into our environment. So, no matter how careful we are or where we live, we all have some level of exposure. Add to this the use of alcohol, tobacco, and prescription, non-prescription, and illicit drugs, and you can see that this has created a challenging task for our bodies to get rid of these substances. The liver carries the greatest burden of detoxifying foreign substances, as well as substances our bodies create (such as hormones). You can help your liver do its job by providing your body with enough protein and the nutrients and botanicals involved in liver function. The typical American diet is high in fats and sugars. It relies heavily on nutrientdepleted vegetables, grains, fruits, and antibiotic and hormone-laden meats. This type of unhealthy diet provides inadequate nutrients for many metabolic processes, including detoxification. These dietary habits, and the fact that many of us eat a limited variety of foods, can result in the development of allergies to some of the most commonly eaten foods, such as corn, wheat, soy, dairy, and eggs.

Increasingly, we find our food supply contaminated with hormones and antibiotics, commonly used in the mass-market farming of animals and in the farm raising of certain fish. Certain types of fish, such as tuna and swordfish, are also known to be high in mercury.


Allergies and exposure to toxins in foods, water, and the environment are being increasingly recognized as major contributing factors in many health problems. The MediClear program is designed to do two things: 1) decrease your exposure to toxins and allergens and 2) help your body cleanse.

MediClear is a rice and pea protein powder with added vitamins, minerals, and specialized nutrients and botanicals that aid in the detoxification process. Rice and pea proteins are used in MediClear because individuals are rarely allergic to them. MediClear contains a high concentration of protein to aid in tissue repair and regeneration. The amino acids in these proteins also help in detoxification and elimination of harmful substances in the body. Other beneficial amino acids, including glycine, N-acetylcysteine (NAC), taurine, and glutathione, are added to assist in this process. Green tea extract provides potent antioxidant and liverprotecting activity and MSM helps detoxification and joint function. A full spectrum of vitamins and minerals, in their most absorbable forms, are also in MediClear to ensure adequate amounts of these nutrients are available for tissue detoxification and regeneration.

Medium chain triglycerides (MCTs) are easily absorbed and used for energy by the body. They do not contribute to increased fat in the bloodstream. The added ingredients in MediClear Plus help maintain a normal inflammatory response. Curcumin, the principal ingredient in the Indian spice turmeric, is an efficient antioxidant that also assists the liver's detoxification activities. Grape seed extract provides potent antioxidant compounds that help strengthen connective tissue and support healing.

PHASE I AND PHASE II DETOXIFICATION
The liver plays a major role in the detoxification of numerous substances in the body, whether they come from the environment, food, or from within the body (from hormones or other substances). In order to metabolize and eliminate these potentially harmful toxins, the liver has developed an intricate, two-step detoxification system. Together, these two phases convert toxins into water-soluble molecules that can be excreted from the body in the stool and urine.

PHASE I DETOXIFICATION
Specific enzymes produced in the liver perform the first step of detoxification. These enzymes, called cytochrome p450 enzymes, help detoxify a number of substances, including medications, caffeine, alcohol, many food constituents, and environmental pollutants. These enzymes cause chemical reactions in the liver that make the above substances more watersoluble. Individuals with an intolerance to caffeine, perfumes, or chemical odors often have a dysfunction in this first phase of detoxification.

PHASE II DETOXIFICATION
The substances from phase I, which are partially detoxified, react with other substances in the liver that convert them into water-soluble compounds that can be eliminated from the body in the urine and stool. A number of cofactors are necessary for this phase to occur, including antioxidants, vitamins, amino acids, and other substances.

The primary nutrients required during phase I detoxification include B vitamins, vitamin C, folic acid, copper, magnesium, and zinc; antioxidants including glutathione, N-acetylcysteine, and lipoic acid; and the branched-chain amino acids leucine, isoleucine, and valine. Phase I detoxification is further enhanced by indole-3-carbinal, found in cruciferous vegetables such as broccoli, Brussels sprouts, cabbage, and cauliflower; and flavonoids, including silymarin from milk thistle, curcumin from the spice turmeric, and polyphenol antioxidants from grape seeds and green tea.

Nutrients required to support phase II detoxification include vitamin B5, vitamin B6, vitamin B12, and vitamin C, folic acid, selenium, zinc, molybdenum, glutathione, and the amino acids glycine, cysteine, methionine, taurine, and glutamine.


Food choices and an exercise program are also important components to a successful detoxification program. For more details on the MediClear program, please download the Patient Guide (which includes healthy recipes and food options) from www.NEEDS.com.


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