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Supporting Healthy Blood Pressure with Oleuropein
Submitted by Life Extension

Advanced Olive Leaf Vascular Support with Celery Seed Extract is a unique, dual-action formulation containing two bioactive compounds that support optimal cardiovascular health.

  1. Olive Leaf extract contains oleuropein, a natural compound that supports healthy blood pressure already within the normal range. Researchers using 1,000 mg per day of olive leaf extract in a controlled clinical trial documented an average 11 mmHg decline in systolic readings and a 4.8 mm Hg drop in diastolic readings within eight weeks.

  2. Celery seed extract contains 3-n-butylphthalide (3nB), which supports a healthy inflammatory response that is critical to maintaining a healthy circulatory system. Celery seed also helps minimize the flow of calcium into the muscle cells lining blood vessels, promoting healthy blood pressure already within the normal range.

In a controlled clinical trial, researchers using an equivalent amount of active compounds as found in this celery seed extract documented an average 8.2 mmHg decline in systolic readings and 8.5 mmHg drop in diastolic readings—in just six weeks.

One particularly fascinating study was conducted among identical twins with borderline hypertension (blood pressure in the range of 120-139 mmHg over 80-89 mmHg). Studies of identical twins virtually eliminate genetic variations which may impact study results. After eight weeks, placebo recipients showed no change in blood pressure from baseline, but patients supplemented with 1,000 mg/day of olive leaf extract dropped their pressures by a mean of 11 mmHg systolic and 4 mmHg diastolic. The supplemented patients experienced significant reductions in LDL cholesterol.

Another study measured olive leaf extract against captopril, one of the conventional drugs used for treating hypertension. In this study, patients with stage-1 hypertension (140-159 mmHg over 90-99 mmHg) took either 500 mg of olive leaf extract twice daily, or 12.5 mg of captopril twice daily, which was increased as needed to 25 mg twice daily. After eight weeks of treatment, both groups experienced a drop in mean blood pressure from baseline (11.5 and 13.7 mmHg systolic; 4.8 and 6.4 mmHg diastolic, respectively), with no significant difference between the two groups. In other words, the olive leaf extract performed as well as the prescription drug. A closer look in the laboratory reveals the reason for this equivalence. Although they utilize different mechanisms of action (oleuropein acts as a natural calcium channel blocker and captopril is a well-known ACEinhibitor), both oleuropein and captopril function inside the vasculature to decrease the tension in the walls of blood vessels and promote widening of the vessels (vasodilation), ultimately lowering blood pressure.

While olive leaf and celery seed extracts show impressive support individually, Advanced Olive Leaf Vascular Support with Celery Seed Extract combines two bioactive compounds to provide dual-action vascular support.


Copyright © 2014. All rights reserved. Reprinted with exclusive permission of Life Extension Magazine®.

REFERENCES
Phytother Res. 2008 Sep;22(9):1239-42.
Inflammopharmacology. 2011 Aug;19(4):227-33.
Asian Pac J Trop Biomed. 2013 Oct;3(10):776-9.
Plant Physiol. 2002 Oct;130(2):675-87.
Natural Medicine Journal. 2013;4(4):1-3.
Phytother Res. 2012 Nov;26(11):1731-7.
Arch Biochem Biophys. 2012 Nov 15;527(2):81-9.


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